Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition

In the face of increasingly serious environmental pollution, health human lung tissues is also facing threats. Mogroside ⅡE (M2E) main metabolite sweetening agents mogrosides from anti-tussive Chinese herbal Siraitia Grosvenori. The study elucidated anti-inflammatory action and molecular mechanism M2E against acute injury (ALI). A lipopolysaccharide (LPS)-induced ALI model was established in mice MH-S cells were employed to explore protective through western blotting, co-immunoprecipitation, quantitative real time-PCR analysis. results indicated that alleviated LPS-induced restraining activation Secreted phospholipase A2 type IIA (Pla2g2a) -Epidermal Growth Factor Receptor (EGFR). interaction Pla2g2a EGFR identified by co-immunoprecipitation. addition, protected induced with LPS inflammatory damage which significantly dependent upon downregulation AKT mTOR via inhibition Pla2g2a-EGFR. may represent a potential target for improvement injury, promising strategy treat ALI.